Folder Guard

Folder Guard is a powerful computer security program that you can use to control access to files, folders, and other Windows resources. You can use Folder Guard to lock your personal files and folders with passwords, to stop other users from peeking into your records.

You can even completely hide your private folders from virtually all applications, and such folders would remain invisible until you enter a valid password. You can also protect sensitive system files from modification or destruction, disable access to the removable drives, restrict access to Control Panel, and more.